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Gold Nanoparticle Cancer Research News 
#6


Originally Posted on 03/23/2018 @ 11:28 am

by Steven Warrenfeltz


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Hello,

For the last seven years, I've been helping people understand how gold nanoparticles offer a better way to treat cancer than today's methods, most notably 'traditional chemo and traditional radiation therapies.'

Gold Nano Blog

Chemotherapy and Radiation kill cancer cells, but they also kill healthy cells.

When radiation and chemotherapy drugs are administered they affect the whole body, the drugs aren't smart, there is no mechanism in them that can direct them to only cancer cells.

Because of this, chemotherapy and radiation drugs have to be given to a patient in very large doses for them to be effective, the result usually comes with a lot of pain in the form of terrible side effects.

Gold Nanoparticles on the hand inherently have a quality about them called the 'EPR Effect' which stands for Enhanced Permeability and Retention Effect - this is a molecular property that gives the Gold Nanoparticles the ability to accumulate in cancer cells more than they do in normal cells.

In addition, this molecular property of Gold nanoparticles was what helped them kill breast cancer cells in an article that was showcased in the last issue of this news report: here, the article can be found under the sub-title of "Gold Nanoparticles Destroy Breast Cancer Cells...Alone."

In addition, gold nanoparticles have a very large surface area which allows them to carry cancer-killing drugs along with cancer finding antibodies, at the same time.

Gold Nanoparticles are inert and research studies have repeatedly proven that they only attack the cancer cells, so there's no life-threatening side-effects associated with this research.  

This is the guide's sixth issue of the Gold Nanoparticle Cancer Research News Report, it covers new GNP cancer research results and some noteworthy news that's been released over the last several weeks.

Below is a glimpse into what you'll find in this issue:

  • World Renown Egyptian Scientist Advocates using Gold Nanoparticles over Chemotherapy for treating Cancer
  • Ultrasound and Gold nanoparticles help a chemotherapy drug do a better job at killing brain tumors
  • Researchers create biodegradable golden crystal nano-flowers

Note:

The medical research articles below have been summarized to make the subject matter a little more understandable, with each summary you'll find direct links to the original articles or research reports.










Egyptian Scientist Advocates
using Gold Nanoparticles to
Replace Chemotherapy

Before I continue with this story, I wanted to let you know that the graphic used for this section, the 'BIOHAZARD CHEMOTHERAPY' sign underneath the 'red circle-backslash symbol' is an image of a 'Real Sign.'

I don't think that I'm alone in thinking "it's not good" when the medicine that is being administered to someone is referred to as a 'biohazard.'

chemotherapy biohazard sign

This first article in this news update comes to us from 'Egypt Today,' the article is titled Chemotherapy must be replaced with gold-based nanoparticles.

The title wasn't a made up, it's a quote from a world-renowned scientist named Mostafa El-Sayed.

Mostafa El-Sayed is an Egyptian chemical physicist, a leading nanoscience researcher, a member of the National Academy of Sciences and a US National Medal of Science laureate. He is also known for the spectroscopy rule named after him, the El-Sayed rule. - wikipedia

Below are Mostafa El-Sayed remark's about Chemotherapy

Chemotherapy has a disastrous side effect for cancer patients, as it does not only kill cancer cells, but also damages healthy cells and can lead to death. - Mostafa Al-Sayed

Mostafa El-Sayed made his comments at the Summit of Nanotechnology at the British University in Cairo.

He went on to say the following statement about using Gold Nanoparticles for treating cancer:

"treatment with gold-based nanoparticles is effective because as the gold nanoparticles react highly to light exposure, the temperature of the particles increases, completely killing the cancer cells that cannot be transferred to another place in the body." - Mostafa Al-Sayed

Mostafa El-Sayed's made
One Mistake in his Comments

Although, most of Mr. Al-Sayed's comments are true, near the end of the article it quotes him as saying the following:

"the effects of the gold treatment on human beings have not been shown yet." - Mostafa Al-Sayed

There is at least one human trial cancer research study that is currently being done involving treating prostate cancer with Gold Nanoparticles at Mount Sinai Hospital in New York City, and so far it has reported very good results.

The video below was released last August by CBS-2 in New York City about this Gold Nanoparticle Cancer Research - Human Trial.

08/01: Researchers Look To Gold To Help Combat Prostate Cancer - link to video above - CBS New York


See the full Egypt Today article here: Chemotherapy must be replaced with gold-based nanoparticles: scientist









Ultra-Sound & Gold Nanoparticles
Helps Chemotherapy
Do a Better Job

Glioblastoma (GBM) is the most common form of brain cancer and it's known as being the most deadly because of its aggressive growth.

It's traditionally treated with surgery (if operable) with chemo and/or radiation therapy.

However, treating this form of cancer with traditional chemotherapy doesn't work well at killing Glioblastoma because it isn't efficient at breaking the blood-brain barrier.

Chemotherapy drugs travel fine through the brain's blood vessels, however, they don't penetrate brain tissue, where the tumors sit.

That's why this study was conducted because there is desperate need to find a better way to deliver chemotherapeutics in the brain.

Gold nanoparticles are known for being able to easily pass through blood vessels without detection.

So researchers attached a chemotherapy drug called Cisplatin to gold nanoparticles to help the drug pass through blood vessels to the brain tissue where the tumor sits.

In addition, researchers used targeted ultrasound waves to intensify the ability of gold nanoparticles to break the blood-brain barrier.

Researchers found that their tests demonstrated that the combination of the of the three factors greatly inhibited the growth of Glioblastoma (GBM) cells compared to traditional forms of therapy.

In their experiments, researchers introduced the Cisplatin coated gold nanoparticle into the bloodstream.

Then as the gold nanoparticles passed near the area of the brain tumor, targeted MRgFUS ultrasound waves helped move the gold nanaparticles from the bloodstream and into the brain tissue.

Results showed that the ultrasound helped the gold nanoparticles to release their chemotherapy drug payload to the cancer cells, killing them. 

'Click' this link here to see a graphic of how the process worked.

All of the information of this research study was collected from the 'Abstract' of the original published paper that was not fully released.

See the Abstract of the research here: Enhancing glioblastoma treatment using cisplatin-gold-nanoparticle conjugates and targeted delivery with magnetic resonance-guided focused ultrasound - Science Direct








Creating Biodegradable
Golden Crystal Nano-Flowers

After it snows, most of us have experienced how hard it can be to see when the sun is out.

Light illuminates off of snow in this way because of how it hits the snow's frozen crystals, it scatters producing more light waves.

When we see this, we wince or put on sunglasses because its hard to see with the light hitting our eyes at so many different angles, this occurrence is called 'snow-blindness.'

Snow & Sun

The same principal is in effect with the tiny gold nano-flowers in this next study, however, light doesn't only bounce off these tiny crystal flowers, the light makes the nano-crystals resonate, which creates heat that kills cancer cells.

This study comes out of Singapore at the  A*STAR Institute of Materials Research and Engineering.

However, the study wasn't conducted so much as to see if the gold nano-flowers would kill cancer cells, although it is proven this study, the study was conducted to find a biocompatible reducing agent for creating gold nano-crystals.

Gold nanoparticles with crystals resemble flowers, which is why they are named 'gold nano-flowers.'

In many cases, when gold nano-crystals are engineered the reducing agent that is added to help the crystals form is often toxic, so it has to be removed before the nano-crystals can be used with a living specimen, which isn't always easy or precise.

In this study, researchers use Starfruit juice as a reducing agent to engineer the crystals on the gold nanoparticles.

star fruit

Their findings were successful because not only did the starfruit juice create viable gold nano-flowers, starfruit juice is biodegradable.

They also found that by using the gold nano-flowers that the starfruit juice created completely killed the cancer cells in the test subjects; as seen here.

Furthermore, the study found out that juices high in vitamin C also known as L-ascorbic acid would work well as a reducing agent to engineer nano-crystals for medical research.

See the full article here: Flower-shaped gold nanocrystals for photothermal therapy - nano werk





One last thing...

To learn more about Gold Nanoparticles and how their specific attributes help kill cancer; 'click here', on the page you’ll learn all there is to know about Gold Nanoparticle Cancer Research

In addition, I recently started The Angel of Healing Cancer Research Fund which supports Gold Nanoparticle Cancer Research, visit this page to learn more about this new fund and the research it supports.



Thank You for your Time.

Take Care & God Bless,

Steve





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