Gold-Nano Blog / Gold Nanoparticle Cancer Research News #4
Originally Posted on 01/29/2018 @ 5:02 pm
Last Updated and Edited on 01/31/2018 @ 2:16 pm
by Steven Warrenfeltz
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Gold Nanoparticles are inert, research studies have repeatedly proven that they only hurt cells they are made to attack, which are cancer cells, so there are no life-threatening side-effects associated with this research.
In this report, you'll find summaries of the most promising and compelling studies, since late November of 2017, in regards to gold nanoparticle medical research.
Below is a glimpse into what you'll find in this issue:
Researchers out of the University of Texas are trying to figure out the best way to developing a microscopic golden nano pill that will kill cancer cells.
In the study, researchers are using supercomputers at the Texas Advanced Computing Center at the University of Texas, as well as supercomputers in San Diego, California, to test how the gold pills would interact inside the body before they create them in the lab.
The goal was to develop a golden nano pill that would navigate through the bloodstream, find cancer cells, then release its payload of cancer-killing drugs when infrared light was shown them.
To clarify, these pills won't be swallowed, nanoparticles are a hundred thousand times smaller than a human hair, instead, large quantities of these gold nano-pills will be injected into a patient's body.
In the article: Dr. Zhenpeng Qin, an assistant professor of Mechanical Engineering and Bio-engineering at the University of Texas at Dallas, stated the following about why they are using supercomputers in the development of these pills:
"A lot of people make nanoparticles and observe them using electron microscopy," Qin said. "But the computations give us a unique angle to the problem. They provide an improved understanding of the fundamental interactions and insights so we can better design these particles for specific applications." Zhenpeng Qin - assistant professor of Mechanical Engineering and Bioengineering at the University of Texas at Dallas
The article goes on to state that Dr. Qin and the research team are testing different combinations of gold nanoparticles, including grouping or compacting gold nanoparticles together to enhance their collective attributes.
In this next study, researchers at Washington State University have developed nanoparticles made of gold and platinum to enhance their tumor-killing properties when heated.
In this study, the researchers targeted the mitochondria of the cancer cell.
Mitochondria are organelles found in cells, and their primary function is to produce energy for the cell, meaning that if the mitochondria are destroyed, the cell cannot survive.
The researchers used highly porous, core-shell gold-platinum
nanoparticles that have a high surface area, which allowed them to
deliver more cancer-killing drugs to the tumor.
Once the Au-Pt nanoparticles were inside the cancer cell's mitochondria, the researchers used a cancer treatment called Photodynamic Therapy (PDT) to activate them.
Photodynamic therapy (PDT) is a treatment that uses a drug called a photosensitizer and light to treat cancer.
When the light of the photodynamic therapy was shown on the gold-platinum nanoparticles, they released the photosensitizing drug, which created a catalytic reaction releasing oxygen through 'Reactive Oxygen Species' (ROS) that killed the cancer cell.
In addition, the researchers found that the gold-platinum nanoparticles enhanced the reaction inside the cell's mitochondrial by creating an ROS burst, making the Photodynamic Therapy (PDT) more lethal to the cancer cells.
In conclusion, the researchers found that gold-platinum nanoparticles made Photodynamic Therapy (PDT) more effective at killing cancer cells.
The lead researcher Annie Du, a professor in the School of Mechanical and Materials Engineering, stated the following about the results of the study:
"The new procedure, if approved for use, will mean fewer side effects for cancer patients." and "Ours is a targeted system, we increase drug concentration in the cancer cell itself, not in other parts of the body. This means physicians can prescribe smaller amounts of drugs." - Annie Du, research professor in WSU’s School of Mechanical and Materials Engineering
CRISPR stands for (Clustered Regularly Interspaced Short Palindromic Repeats), it is a genome-editing tool that splices then edits DNA.
It inhibits bad genes by removing a defective DNA strand and replacing it with a corrected strand of DNA code.
CRISPR-Cas9 has had lots of good results in several 'in vitro' or in the lab cancer research studies, but one big problem for this research that the genome-editing tool has a problem with is getting to its expected destination in a living specimen.
Plus, researchers have found out that the longer the CRISPR-Cas9 DNA-editing-tool hangs around in the body, the more it becomes a threat to the body because it could make unwanted 'edits.'
The last research study in this GNP Cancer Research News Report comes out of Beijing, China, at its National Center for NanoScience and Technology.
The researchers noted that they chose gold nanoparticles because they can be easily modified for various biological molecules.
In the study, once the gold nanoparticles found their targets, lasers were used to separate the CRISPR-Cas9 gene-editing tool from its nano-gold delivery vehicle.
When the separation occurred, this enabled the CRISPR-Cas9 gene editing to knockout of the targeted gene killing the cancer cells and inhibiting tumor growth.
The study has provided more positive results for using Gold Nanoparticles as CRISPR-Cas9's delivery system.
Plus, the research notes that gold nanoparticles add a complementary factor to aiding CRISPR-Cas9 by acting as a thermo-therapeutic agent.
The following is stated about the findings of the study:
“In summary, this relatively simple design using gold nanoparticles, peptides, and lipids assembled into a sophisticated multifunctional carrier/release system could serve as a multifunctional delivery platform for various aspects of gene therapy.”
Furthermore, The Director of NIH (National Institute of Health) recently wrote in his blog some encouraging words about using Gold Nanoparticles as the delivery system for CRISPR-Cas9.
You can see what the Director of NIH wrote here: Gene Editing: Gold Nanoparticle Delivery Shows Promise - National Institute of Health’s - ‘Director’s Blog.’
Please help this guide spread the word about Gold Nanoparticle Medical/Cancer Research by forwarding this blog post to a friend, or a subject related website / forum.
Thank You for your Time.
Take Care & God Bless,
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