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Gold Nanoparticle Cancer Research Report
#11


Originally Posted on 10/16/2018 @ 8:52 pm EDT

by Steven Warrenfeltz


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Hello,

For the last seven years, this website has been informing people about the many ways gold nanoparticles offer a better way to treat cancer than today's methods.

Gold Nano Blog

Gold Nanoparticles are non-toxic, bio-compatible, and they can be made to attack and kill ONLY cancer cells, so in most cases there are no life-threatening side-effects associated with this research.  

Below is a glimpse into what you'll find in this issue:

  • Nano Gold & Iron make MRI's safer and better
  • Treating Brain Cancer using a Gold Nanoparticle Nasal Spray

Note:

The medical research articles below have been summarized to make the subject matter more understandable, with each summary you'll find direct links to the original articles and/or research reports.









Making MRI's
Better and Safer using
Gold (Au) & Iron (Fe)

If you've ever had an MRI, (Magnetic Resonance Imaging) you know that they can be a little claustrophobic and loud. 

MRI Lab

The confined atmosphere of an MRI machine is due to the fact that a person is literally asked to lay inside a large electromagnet, plus the loud noise is from the energy used to create that magnetic field that aligns the protons in your body.

A Magnetic Resonance Image occurs after a radio frequency has been added and removed to the electromagnetic field which disrupts the protons in the body, creating an image.

To enhance the image, traditionally, MRI technicians inject a drug or contrast agent containing gadolinium into the patient's body.

Gadolinium is a toxic rare earth metal and is the traditional contrast agent given to patients who are having an MRI.

gold and iron

When Gadolinium is manufactured, as a contrast agent, it is placed in an organic wrap that reduces an individuals exposure of the metal's toxicity and helps it pass through the body.

However, in a Japanese study gadolinium was found to accumulate in the brains of some patients and other studies found deposits of the metal in other areas of the body.

Although no toxicity from the gadolinium was found in those studies, the findings were alarming, and the FDA has made drug manufactures add warnings about the gadolinium based drugs.

This is why researchers out of Rice University in Houston, Texas, have developed a new way to make Magnetic Resonance Images safer with enhanced imaging by using a new contrasting agent consisting of gold nanoparticles, iron, and fluorescent dyes.

In the study, the researchers called their new contrasting agent a 'Nano-matryoshkas,' after the Russian nesting dolls, because they are multilayered.

The nano-matryoshkas are assembled with a gold nanoparticle core that's covered with a silica layer that encapsulates iron molecules called 'chelates' and fluorescent dyes (contrasting agents), then another layer of gold is added for protection.

(Courtesy of: Luke Henderson/Rice University)

When the researchers used the gold-based nanomatryoshkas in experimental MRI's, they stated that the "results surprised everyone."

This was because gold nanoparticles have a very large surface area, and this abundant space enabled the researchers to overload the particles with iron chelates, which made the nanomatryoshkas perform twice as well as clinically available gadolinium chelates.

In addition, the lead researcher in the study, Dr. Naomi Halas, stated that the gold-based nanomatryoshkas can kill cancer cells when a near-infrared light is focused on them.

So with further research, these experiments may one day give individuals the ability to diagnose and treat cancer in a single visit to the MRI lab.

Lastly, this study was headed up by Dr. Naomi Halas, who invented 'Nanomatryoshkas and nanoshells' twenty years ago at Rice University, and she is also one of the listed researchers that the Angel of Healing Cancer Research Fund supports.


Read the full research report here: Reimagining MRI contrast: Iron outperforms gadolinium - Rice University









Treating Brain Cancer using a
Gold Nanoparticle
Nasal Spray


Blood-flow to BrainBlood-flow to the Brain

Current forms of treating brain cancer involve surgery, if operable, but usually it is treated with chemo and/or radiation therapy, and often with poor results.

These poor results come from modern-day treatments failure to break the Blood-Brain Barrier.

That is why researchers at the Washington University in St. Louis, Missouri have come up with an ingenious way to break the 'blood-brain barrier' with a nasal spray (intranasal delivery) that treats and kills brain cancer cells.

The researchers did this using gold nanoparticles, micro-bubbles, and Focused Ultra-Sound.

In their study, they first attached a cancer fighting drug to gold nanoparticles and introduced them into the brain using a nasal spray.

When the spray is introduced to the nasal cavity, the gold nanoparticles are absorbed by Olfactory and Trigeminal nerves, bypassing the blood-brain barrier.

However, in an odd twist to this research, it is the heart's pumping effect on the vessels in the body that help to distribute the gold nanoparticles and the drug into the brain.

Once the gold nanoparticles fully penetrated the brain, micro-bubbles were injected into the body, and 'Focused Ultra-Soundwaves' were focused onto the brain cancer.

The combination of the Focused Ultra-Sound and the micro-bubbles,  propelled the drug-coated gold nanoparticles into the cancer cells, killing them.


Researchers stated the following about their results:

"... results suggest that FUSIN (Focused Ultra-Sound IntraNasal delivery) is a promising technique for noninvasive, spatially targeted, and safe delivery of nanoparticles to the brain with minimal systemic exposure."


Read the Abstract here: Focused ultrasound combined with microbubble-mediated intranasal delivery of gold nanoclusters to the brain - Science Direct

University Article here: Focused delivery for brain cancers - University of St. Louis








One last thing...

To learn more about Gold Nanoparticles and how their distinct qualities  help kill cancer; 'click here', on the page you’ll learn all there is to know about the research.

In addition, please help this guide support Gold Nanoparticle Cancer Research through its Angel of Healing Cancer Research Fund.



Thank You for your Time.

Take Care & God Bless,

Steve






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